ABSTRACT
To determine the status of HDV infection in HBV infected individuals at Larkana. This is a laboratory based retrospective study conducted at Molecular Laboratory PHCP-CMI Central laboratory CMC Hospital City block Larkana from October 2010 to September 2011. During the study period all the serum samples in which the HBV DNA was qualitatively detected were further processed for HDV RNA detection by the method of Real time PCR. During the study period a total of 1564 HBV DNA detected serum samples were processed for HDV RNA detection. The males were 1078 [69.0%] and females 486 [31.0%]. The age were ranged between 15 to 73 years. Out of the 1564 HBV DNA detected serum samples, the HDV RNA was detected in 865 [55.31%] and not detected in 699 [44.69%] individuals. This study showed 55.3% HDV infection in the HBV infected patient. Hence, to formulate the treatment option and to predict the response of treatment it is necessary that every HBV infected case should be processed for HDV RNA detection